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Either your web browser doesn't support Javascript or it is currently turned off. In the latter case, please turn on Javascript support in your web browser and reload this page. Free to read. For additional information, or to request that your IP address be unblocked, please send an email to PMC. For requests to be unblocked, you must include all of the information in the box above in your message. Read article at publisher's site DOI : NPJ Vaccines , , 20 Sep Front Immunol , , 09 Aug Virology , , 22 Oct Iwasaki A.


If you happen to be in the Reno area this week, you might see some strange-looking vehicles, some running under their own power, but most riding on trailers.

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Osmond J. This study examined the potential utility of PHI as a nonspermicidal microbicide for prevention of sexual transmission of HIV. Our goal in this study was to test the effects of PHI on in vivo sperm functions under conditions shown to inactivate viruses in human cells. Exposure of rabbit semen to PHI either ex vivo or in vivo had no adverse impact on in vivo fertilizing ability in the rabbit model. Reproductive indices i. Repeated intravaginal administration of 0. PHI has clinical potential as a prophylactic broad-spectrum anti-HIV microbicide without contraceptive activity. In the absence of an effective prophylactic anti-HIV therapy or vaccine, current efforts are aimed at developing effective and safe intravaginal as well as intrarectal topical formulations of antiviral microbicides to prevent the sexual HIV-1 transmission [ 3 , 4 ]. Semen is an important vehicle for cell-associated transmucosal transmission of HIV-1 [ 5 ]. Microbicides could provide protection by directly inactivating HIV or preventing HIV from attaching, entering, or replicating in susceptible target cells as well as dissemination from target cells present in semen or the host cells that line the vaginal or rectal wall.

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